普鲁士蓝
葡萄糖氧化酶
生物传感器
化学
检出限
Nafion公司
碳纳米管
纳米技术
电极
纳米复合材料
电化学
色谱法
材料科学
物理化学
作者
Yingying Xiao,Lanlan Hou,Mengzhu Wang,Ruping Liu,Lu Han,Mukhurov Nikolai,Siqi Zhang,Chuantong Cheng,Kuan Hu
标识
DOI:10.1016/j.aca.2023.342068
摘要
Wearable biosensors have gained huge interest due to their potential for real-time physiological information. The development of a non-invasive blood glucose device is of great interests for health monitoring in reducing the diabetes incidence. Here, we report a sandwich-structured biosensor that is designed for glucose levels detection by using sweat as the means of monitoring. The Prussian blue nanoparticles (PBNPs) and carboxylated carbon nanotubes (MWCNT-COOH) were self-assembled on the electrode to improve the electrochemical performance and as the sensor unit, glucose oxidase (GOx) was immobilized by chitosan (CS) as the reaction catalysis unit, and finally encapsulated with Nafion to ensure a stable performance. As a result, the GOx/PBNPs/MWCNT-COOH sensor displays a low detection limit (7.0 μM), high sensitivity (11.87 μA mM−1 cm−2), and excellent interference resistance for a full sweat glucose application range (0.0–1.0 mM) for both healthy individuals and diabetic patients. Additionally, the glucose sensor exhibits stable stability for two weeks and can be successfully applied to screen-printed carbon electrodes (SPCE), demonstrating its great potential for personalized medical detection and chronic disease management.
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