肿瘤坏死因子α
牙槽
体内
自愈水凝胶
再生(生物学)
细胞毒性
医学
免疫学
化学
体外
癌症研究
材料科学
细胞生物学
牙科
生物
生物化学
高分子化学
生物技术
作者
Peng Liu,Wei Li,Guohua Peng,Danfeng Wei,Liping Gou,Ye Zhou,Yong Zhou,Marc E. Rothenberg,Lei Wu,Wanli Zhang,Liqiang Hu,Qian Cao,Chengshi Wang,Y Zhang
标识
DOI:10.1002/marc.202300559
摘要
Abstract Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments. Rebuilding diabetic alveolar bone in clinics is currently challenging due to persistent infection and inflammatory response. Here, an antibacterial DNA‐based hydrogel named Agantigel is developed by integrating silver nanoclusters (AgNCs) and tumor necrosis factor‐alpha (TNF‐ α ) antibody into DNA hydrogel to promote diabetic alveolar bone regeneration. Agantigel can effectively inhibit bacterial growth through AgNCs while exhibiting negligible cytotoxicity in vitro. The sustained release of TNF‐ α antibody from Agantigel effectively blocks TNF‐ α and promotes M2 polarization of macrophages, ultimately accelerating diabetic alveolar bone regeneration in vivo. After 21 days of treatment, Agantigel significantly accelerates the defect healing rate of diabetic alveolar bone up to 82.58 ± 8.58% and improves trabecular architectures compared to free TNF‐ α (42.52 ± 15.85%). The results imply that DNA hydrogels are potential bio‐scaffolds helping the sustained release of multidrug for treating DABI or other oral diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI