化学
烯丙基重排
催化作用
铂金
组合化学
药物化学
有机化学
作者
Junpei Shimosato,Masaya Sawamura,Yusuke Masuda
标识
DOI:10.1021/acs.orglett.4c00091
摘要
A unique process for the photoinduced platinum-catalyzed reductive allylation of α-diketones with allylic carbonates has been developed. This allylation reaction was found to proceed selectively at the more electron-deficient carbonyl group of the diketone to afford an α-keto homoallylic alcohol. Such products could be further derivatized by transformation of the remaining carbonyl group. A mechanistic investigation suggests that a ketyl radical generated in response to photoirradiation reacts with a (π-allyl)platinum complex to form a C–C bond.
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