tHIS way to cognitive development

The effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal associations between microbiota composition, cognitive scores, and histidine metabolism. The effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal associations between microbiota composition, cognitive scores, and histidine metabolism. Infant gut microbiota contributes to cognitive performance in miceCerdó et al.Cell Host & MicrobeDecember 4, 2023In BriefGut microbiota composition is associated with infant neurodevelopment. Here, Cerdó et al. use compositional, metaproteomic, and histidine metabolomic analyses to reveal a link between infant cognition and gut microbiota. The transfer of gut microbiota from infants with better cognition promotes memory and modulates histidine metabolome in the perirhinal cortex (PRC) of mice. Full-Text PDF