免疫疗法
癌症研究
癌症
癌基因
福明
癌症免疫疗法
肿瘤微环境
免疫系统
生物
免疫学
医学
细胞
内科学
细胞周期
遗传学
肌动蛋白细胞骨架
细胞骨架
作者
Jie Mei,Yun Cai,Huiyu Wang,Rui Xu,Jiaofeng Zhou,Jiahui Lü,Xuejing Yang,Jiadong Pan,Chaoying Liu,Junying Xu,Yichao Zhu
标识
DOI:10.1016/j.clim.2022.109204
摘要
Formins are evolutionarily conserved genes and profoundly affect cancer progression. This study aims to explore the expressions, prognostic values, and immunological correlations of Formins in cancer. Specific Formins were dysregulated and immuno-biologically correlated in breast cancer (BRCA). Formins showed different expression patterns, namely some were enriched in immune cells while some were enriched in tumor cells. Among all Formins, DIAPH1 was enriched in tumor cells and associated with an inflamed tumor microenvironment (TME). DIAPH1 functioned as an oncogene in BRCA and mediated TGF-β1-induced epithelial-mesenchymal transformation (EMT) and PD-L1 expression. Moreover, DIAPH1 was overexpressed in most cancers and functioned as a novel pan-cancer immuno-marker, which could predict the response to anti-PD-1/PD-L1 immunotherapy. Overall, DIAPH1 functions as an oncogene and is immunologically correlated, which could be utilized as an alternative biomarker for predicting the immunotherapeutic response.
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