Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Due to their electron coupling capability, organic luminescent materials exhibit powerful optoelectronic features that are responsible for their light-harvesting and light-amplification properties. The extensive modification of conjugated systems has shown significant improvement in their photonic properties thus broadening their applicability in photo-mediated imaging and photo-based treatment. Organic luminogens with emission in the near-infrared second region are found attractive not only for their deeper penetrating power but also for accurate visual imaging superiority with higher temporal resolution and spatial resolution suitable for tumor precision treatment. In this review, we underscore the latest development in organic luminogens (conjugated polymers and small molecules), focusing on chemical design, molecular engineering, and their applications in the scope of bioimaging followed by photo-assisted treatment, including photodynamic therapy (PDT), photothermal therapy (PTT), and immunotherapy ablation. Organic luminogens integrated with an aggregation-induced emission feature significantly optimize their physicochemical properties to act as quintessential nanoplatforms for controllable image-guided therapy. In conclusion, we clarify the limitations and challenges and provide insights into how to design organic dyes with improved safety for potential clinical applications.