化学
炔烃
分子内力
烯烃
催化作用
铜
组合化学
药物化学
立体化学
有机化学
作者
Fang Zhang,Shuaifeng Wang,Zhicheng Liu,Yihui Bai,Gangguo Zhu
标识
DOI:10.1016/j.tetlet.2017.02.059
摘要
We report here a room temperature, efficient, and broadly applicable copper-catalyzed borylative cyclization of 1,n-enynyl (n = 6–9) phosphates for the concise synthesis of structurally diverse 5–8 membered cyclic 1,4-dienyl boronates, which represents the first Cu-catalyzed formal intramolecular alkyne allylboration. Subsequent Suzuki-Miyaura coupling provides a facile access to cyclized 1,4-dienes. A mechanism consisting of alkyne borylcupration, intramolecular alkene addition, and β-elimination has been proposed to explain the experimental results.
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