急性呼吸窘迫综合征
医学
背景(考古学)
促炎细胞因子
病理生理学
重症监护医学
弥漫性肺泡损伤
分子生物标志物
急性呼吸窘迫
病理
肺
内科学
炎症
生物
古生物学
作者
Yasmeen M. Butt,Anna Kurdowska,Timothy Craig Allen
出处
期刊:Archives of Pathology & Laboratory Medicine
[Archives of Pathology and Laboratory Medicine]
日期:2016-04-01
卷期号:140 (4): 345-350
被引量:587
标识
DOI:10.5858/arpa.2015-0519-ra
摘要
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of lung changes arising from a wide variety of lung injuries, frequently resulting in significant morbidity and frequently in death. Research regarding the molecular pathophysiology of ALI/ARDS is ongoing, with the aim toward developing prognostic molecular biomarkers and molecular-based therapy.Context.— To review the clinical, radiologic, and pathologic features of ALI/ARDS; and the molecular pathophysiology of ALI/ARDS, with consideration of possible predictive/prognostic molecular biomarkers and possible molecular-based therapies.Objective.— Examination of the English-language medical literature regarding ALI and ARDS.Data Sources.— ARDS is primarily a clinicoradiologic diagnosis; however, lung biopsy plays an important diagnostic role in certain cases. A significant amount of progress has been made in the elucidation of ARDS pathophysiology and in predicting patient response, however, currently there is no viable predictive molecular biomarkers for predicting the severity of ARDS, or molecular-based ARDS therapies. The proinflammatory cytokines TNF-α (tumor necrosis factor α), interleukin (IL)–1β, IL-6, IL-8, and IL-18 are among the most promising as biomarkers for predicting morbidity and mortality.Conclusions.—
科研通智能强力驱动
Strongly Powered by AbleSci AI