离体
体内
缺血
医学
动物模型
再灌注损伤
心肌缺血
心肌梗塞
转基因小鼠
转基因
心脏病学
内科学
生物
生物技术
生物化学
基因
作者
Jan Mersmann,Kathrina Latsch,Katharina Habeck,Kai Zacharowski
出处
期刊:Shock
[Ovid Technologies (Wolters Kluwer)]
日期:2011-05-01
卷期号:35 (5): 449-455
被引量:12
标识
DOI:10.1097/shk.0b013e318208af64
摘要
Myocardial ischemia/reperfusion injury (MI/R) is one of the most prominent topics of contemporary research. The frequent failure of potential therapeutic drugs and interventions to transfer to clinical practice demonstrates the limitations in using experimental animal models. Because a variety of transgenic animals are readily available in mice, researchers in recent years have made use of murine models rather than of larger animal models for experimental MI/R. This review focuses on in vivo and ex vivo murine models of MI/R and aims to characterize the source of our mechanistic understanding in mice. A systematic review of the literature demonstrated that there is great diversity among ex vivo (Langendorff) and in vivo models of MI/R.
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