Effects of Exercise Training on Myocardial Nitric Oxide Synthase and Cell Adhesion Molecule in Rats with Hyperlipidemia

Objective To investigate the effects of exercise training on myocardial nitric oxide synthase(NOS) and cell adhesion molecules(CAMs) in rats with hyperlipidemia.Method SD rats were randomly divided into three groups:control group,hyperlipidemia model group and hyperlidiemia and aerobic exercise group.Our study used immunohisto-chemistry of SABC determining the expressions of myocardial eNOS,iNOS,nNOS,ICAM-1 and VCAM-1.Results Comparing with the control group,the expression of myocardial eNOS,iNOS and nNOS were significant reduce and the expression of ICAM-1 and VCAM-1 were significant increase in the rats with hyperlipidemia(P0.05).Comparing with the hyperlipidemia model group,the experssion of myocardial eNOS,iNOS and nNOS were increased significantly and the expression of ICAM-1 and VCAM-1 were reduced significantly in the rats with hyperlipidemia and aerobic exercise.The results showed the expression changes of myocardial eNOS,iNOS,nNOS,ICAM-1 and VCAM-1 in rats with hyperlipidemia were caused by aerobic exercise.Conclusion Hyperlipidemia can downregulate the expression of NOS and upregulate the expression of CAMs;aerobic exercise might protect against the atherogenic effects of hyperlipidemia by upregulating the expressions of NOS and downregulating the CAMs.