A Control Study On The Treatment Of Obsessive-compulsive Disorder With Venlafaxine

Objective:To compare the efficacy and safety of venlafaxine and clomipramine in the treatment of obsessive compulsive. Methods:Sixty patients who met the diagnostic criteria of CCMD-3 were randomly divided into venlafaxine group and clomipramine group to treat for eight weeks.The efficacy and side effects were evaluated by Y-Bocs 、CGI-SI and TESS before treatment and after eight weeks.Results: Both drugs were similar in effect,and the efficacy was obvious after eight weeks(P0.01).The effective rate of venlafaxine group and clomipramine group were 80%and 79%,but venlafaxine took effect more quickly and its side effects were less and milder.Conclusions: Venlafaxine is an effective and safe antidepressant in the treatment of obsessive-compulsive disorder.It can be generally used in the treatment of obsessive-compulsive disorder.