Lipases are the most widely used class of enzymes in organic synthesis due to their high selectivity, mild reaction conditions, environmental acceptability, etc. This article reviews the new progress on lipases catalyzed C-C bond formation reactions, such as aldol condensation, Knoevenagel condensation, Michael addition, Henry reaction, etc. Keywords lipase; aldol condensation; Knoevenagel condensation; C-C bond formation C-C , [13] , , , [46] . , [79] , C-C , [1012] . (lipase, E.C.3.1.1.3) C