皮密莫司
TRPV1型
瞬时受体电位通道
辣椒素
皮肤病科
敏感皮肤
伤害
灼热感
医学
钙调神经磷酸酶
感觉
感觉系统
药理学
作者
Zhi-Qiang Xie,Yu-zhen Lan
出处
期刊:Acta Academiae Medicinae Sinicae
日期:2012-08-01
卷期号:34 (4): 375-8
标识
DOI:10.3881/j.issn.1000-503x.2012.04.012
摘要
To investigate the effectiveness of pimecrolimus cream 1% for sensitive skin in adult women and its underlying mechanisms.The changes of subjective symptoms and signs were evaluated before and after the application of pimecrolimus cream 1% based on the severity of pruritus (SP) and severity of burning sensation (SB) scores, and on a basic syntax and molecular substrate (molecular psychophysics) of nociception and proprioception established by temperature-sensitive transient receptor potential (TRP) channels.The SP and SB scores were significantly decreased in 32 patients with sensitive skin after using topical pimecrolimus cream 1% (P<0.05). Twenty (62.5%) patients showed positive capsaicin-like response (i.e. burning with consequent rapid amelioration of pruritus or burning sensation) and 6 (18.8%) showed positive camphor-like response (i.e. warming with consequent rapid amelioration of pruritus) on application sites after using the topical pimecrolimus cream 1%, and 6 (18.8%) showed negative capsaicin-like response and/or negative camphor-like response.Pimecrolimus may rapidly inhibit or alleviate itch or burning sensation of patients with sensitive skin. The therapeutic effect of pimecrolimus is relevant to the mechanisms that activate or sensitize transient receptor potential vanilloid 1 (TRPV1) and desensitizes TRPV1 in the skin sensory afferents.
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