[Effect of peptide bioregulators and cytokines on life span and age-related changes of hemostasis].

The review considers literature data and own results of research of cytokines functions and their effects on hemostatic system and life span. The data of age-related changes in the hemostatic system is presented in this article. A big part of the review is devoted to the action of regulatory peptides (RP) on various body systems. It is established that the RP can normalize the expression of cytokine genes in humans and animals with stress and pathological conditions. Effect of RP on the cytokines has geroprotective action, which is based on anti-oxidant, anti-inflammatory action, stimulation of cell proliferation and differentiation, as well as a normalizing effect on the immune system and hemostasis.