Abstract The rectum and anus chapter explains diseases and conditions of the rectum and anus. The diseases of the rectum and anus are explored with the common presenting symptoms identified. The occurrence rates of these conditions are defined and any potential causes listed. The investigations that are required to diagnose the conditions are described. Treatment options or preventative measures are also explained with identification of any potential complications. There are many conditions that can affect the rectum and anus including rectal prolapse, haemorrhoids, pilonidal sinus, and rectocele. Other conditions include anorectal abscess, anal fistula, anal warts, and anal fissure. Succinct descriptions of caring for people with diseases and conditions of the rectum can increase the knowledge of the nurse.