医学
免疫系统
免疫学
过敏
低丙种球蛋白血症
药品
免疫病理学
免疫疗法
免疫球蛋白E
抗体
药理学
标识
DOI:10.1016/j.iac.2020.06.003
摘要
Biologic and other therapies used for the treatment of immune-mediated hypersensitivity conditions, and in people with immune-mediated hypersensitivity, can trigger a wide variety of immune-related adverse drug reactions and immunologically mediated drug hypersensitivities. These range from acute-onset immunoglobulin E–mediated allergies to delayed-onset T-cell–mediated hypersensitivities. Certain therapeutic and diagnostic agents can directly activate mast cells. Biologic agents used to treat immune-mediated hypersensitivity can also globally upregulate or downregulate the immune system leading to pathologic reactions, including cytokine storm and hypogammaglobulinemia.
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