The Potential of TPP Chitosan Nanoparticles as Carrier for Poorly Soluble Rosiglitazone Maleate

The objective of this study is to develop biodegradable sub-micron chitosan nanoparticles loaded with rosiglitazone maleate for intravenous drug targeting.The rosiglitazone maleate loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tri polyphosphate anions (TPP).The effects of chitosan concentration and sodium tri polyphosphate on the physicochemical properties of the nanoparticles were studied.The particle size and zeta potential of nanoparticles were determined, respectively by transmission electron microscopy (TEM) and a zeta potential analyzer.It was found that the nanoparticles showed a size distribution in the range of 86 nm -110 nm with spherical morphology and smooth surface structure.The encapsulation efficiency decreased with the increase of chitosan concentration.These studies showed that chitosan can form complex with tri polyphosphate anions to form stable cationic nanoparticles for subsequent rosiglitazone maleate.In vitro release studies showed a burst effect at the beginning and then a sustained release characteristic for 32 h.The study on the drug to polymer ratio showed a linear relationship between the concentration of drug and percentage drug loading.