胎盘形成
滋养层
生物
表观遗传学
胎盘
功能(生物学)
后生
干细胞
细胞生物学
计算生物学
生物信息学
胎儿
遗传学
DNA甲基化
怀孕
基因
基因表达
作者
Myriam Hemberger,Courtney W. Hanna,Wendy Dean
标识
DOI:10.1038/s41576-019-0169-4
摘要
The importance of the placenta in supporting mammalian development has long been recognized, but our knowledge of the molecular, genetic and epigenetic requirements that underpin normal placentation has remained remarkably under-appreciated. Both the in vivo mouse model and in vitro-derived murine trophoblast stem cells have been invaluable research tools for gaining insights into these aspects of placental development and function, with recent studies starting to reshape our view of how a unique epigenetic environment contributes to trophoblast differentiation and placenta formation. These advances, together with recent successes in deriving human trophoblast stem cells, open up new and exciting prospects in basic and clinical settings that will help deepen our understanding of placental development and associated disorders of pregnancy.
科研通智能强力驱动
Strongly Powered by AbleSci AI