表观遗传学
血管生成
肺癌
转移
癌症研究
组蛋白
癌症
生物
DNA甲基化
癌症表观遗传学
表观遗传疗法
医学
生物信息学
遗传学
病理
DNA
基因表达
基因
组蛋白甲基转移酶
作者
Heng Wee Tan,Yan‐Ming Xu,San‐Hai Qin,Guo‐Feng Chen,Andy T. Y. Lau
摘要
Abstract Lung cancer is the leading cause of cancer‐related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs. Here, we review the current knowledge of the epigenetic regulation of angiogenesis and discuss the potential clinical applications of epigenetic‐based anticancer therapy in lung cancer. Overall, epigenetic‐based therapy will likely emerge as a prominent approach to treat lung cancer in the future.
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