This chapter reviews typologies of safety culture, which reflect an organization’s core values and assumptions about safety, and related research on safety culture and safety climate. It integrates research on key aspects of an effective safety culture, including leadership, teamwork, employee participation, encouraging employees to speak up about safety, and the relationship between safety culture and safety climate. Ways of organizing and managing safety are discussed in the context of ensuring that organizations implement best practice interventions to reduce accidents and improve organizational safety performance.