放射治疗
缺氧(环境)
体内
癌症治疗
肿瘤微环境
辐射
充氧
氧气
化学
癌症研究
双重角色
催化作用
生物物理学
癌症
肿瘤缺氧
组合化学
生物化学
生物
肿瘤细胞
医学
有机化学
遗传学
内科学
物理
量子力学
作者
Shuxin Lv,Wei Long,Junchi Chen,Qinjuan Ren,Junying Wang,Xiaoyu Mu,Haile Liu,Xiaodong Zhang,Ruiping Zhang
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2020-01-01
卷期号:12 (2): 548-557
被引量:21
摘要
Hypoxia is known to be a common feature within many types of solid tumors, which is closely related to the limited efficacy of radiotherapy. Meanwhile, due to the non-discriminatory killing effect of both normal and cancer cells during the radiation process, traditional radiosensitizers could bring severe non-negligible side-effects to the whole body. In this work, stable and atomically precise Mn clusters which possess efficient pH-triggered catalytic selective capacity are developed rationally. Mn clusters could efficiently catalyze oxygen production in an acidic tumor microenvironment, while exhibiting strong reducibility and free radical scavenging ability in neutral circumstances. In vivo experiments show that Mn clusters are able to enhance the radiotherapy effect in the mouse model of 4T1 tumors and protect normal tissues from radiation at the same time. Thus, the present work provides a novel dual-functional strategy to enhance radiotherapy-induced tumor treatment by improving tumor oxygenation and protect normal tissues from radiation simultaneously.
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