On nervous ganglion of snail Helix pomatia was shown the effect of dephosphorylated core of 2',5'-oligoadenylate (2',5'-ApApA) on pacemaker electrical activity of RPa2 snail neurons. In experiments, solution of 2',5'-ApApA in concentration 5 x 10(-5) mol/l effected snail nervous ganglion in the course of 2 min then it was washed in the course of 2 hours.