细胞疗法
自身免疫
过继性细胞移植
临床试验
疾病
移植
Treg细胞
移植排斥反应
调节性T细胞
移植物抗宿主病
细胞
医学
生物
免疫系统
免疫学
T细胞
病理
内科学
白细胞介素2受体
遗传学
作者
Caroline Raffin,Linda T. Vo,Jeffrey A. Bluestone
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-12-06
卷期号:20 (3): 158-172
被引量:395
标识
DOI:10.1038/s41577-019-0232-6
摘要
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describe new efforts in Treg cell engineering to enhance specificity, stability, functional activity and delivery. Finally, we envision that the success of Treg cell therapy in autoimmunity and transplantation will encourage the clinical use of adoptive Treg cell therapy for non-immune diseases, such as neurological disorders and tissue repair.
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