Chlorogenic acid ameliorates obesity by preventing energy balance shift in high‐fat diet induced obese mice

Abstract BACKGROUND Chlorogenic acid is a type of phenolic acid found in many plants. Chlorogenic acid has an anti‐obesity effect with an unclear mechanism. The present study aimed to investigate the regulatory effect of chlorogenic acid on energy balance in high‐fat diet (HFD) induced obese C57BL/6J mice administrated 100 mg kg –1 chlorogenic acid for 13 weeks. RESULTS The consumption of chlorogenic acid ameliorated HFD induced obesity. Chlorogenic acid did not change the physical activity but significantly decreased food intake and increased body temperature, thermal dissipation and brown adipose tissue activity. Moreover, chlorogenic acid improved glucose tolerance but had a moderate impact on other blood indices. Additionally, chlorogenic acid failed to restore the microbiota change associated with HFD induced obesity, but modified the gut bacterial composition in a unique way. CONCLUSION Supplementation with chlorogenic acid can improve HFD induced obesity and associated glucose intolerance mainly via regulating food intake and energy expenditure. © 2020 Society of Chemical Industry