Synthesis of Allenic Amino Acids via Chelate-Controlled Ester Enolate Claisen Rearrangement

All articles of this category Ester enolate Claisen rearrangement of amino acid propargylic esters 6 allows the synthesis of sensitive amino acids 8 . This methodology is suitable not only for glycine derivatives but also for propargylic esters of various amino acids. In this case amino acids with quaternary α -carbon centers are formed. Claisen rearrangement - amino acids - allene - chelate-enolate - propargylic esters