伤口愈合
生物相容性
复合数
细菌纤维素
聚乙二醇
膜
生物医学工程
体内
再生(生物学)
抗菌剂
化学
材料科学
纳米技术
纤维素
复合材料
外科
医学
细胞生物学
生物化学
有机化学
生物技术
生物
作者
Yansen Wang,Wang Cai,Yu Xie,Yingying Yang,Yudong Zheng,Hui Meng,Wei He,Ke Qiao
标识
DOI:10.1016/j.carbpol.2019.114985
摘要
In recent years, bacterial cellulose (BC)-based dressings or patches for skin or soft tissue repair have become investigative emphasis. However, most of the BC-based products used for biomedical applications present limitations due to their low flexibility, poor gas permeability and no inherent antibacterial activity. Herein, we proposed and designed a novel composite composed of natural bacterial cellulose (BC), polyethylene glycol (PEG) and polyhexamethylene biguanidine (PHMB) through new synthetic approaches. The composite membrane exhibited favorable physicochemical performance, especially transparency, water retention ability, flexibility as well as the characteristic of anti-adhesion. In vitro biochemical experiment results indicated that the composite had excellent biocompatibility and exhibited strong and sustained antibacterial effect. In vivo test further demonstrated that the composite could efficiently promote skin wound healing and regeneration in a rat model. This composite membrane possesses multiple mechanisms of promoting cutaneous wound healing and will provide new ideas for future development of wound dressings.
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