Visualization of varying MT1-MMP expression with a phage display derived bicyclic peptide using µPET imaging

Tumor-associated membrane type 1 matrix metalloproteinase (MT1-MMP) is reported to play an important role in extracellular matrix remodeling, resulting in metastatic dissemination, and to be associated with poor prognosis in a variety of cancers (e.g. non-small cell lung cancer, gastric and breast cancer). This study investigates the potential of a novel phage display derived bicyclic peptide to distinguish between different MT1-MMP-expression levels using small animal PET imaging.