间质细胞
胰腺癌
肿瘤微环境
旁分泌信号
转移
免疫系统
细胞外基质
癌相关成纤维细胞
癌症研究
医学
转化研究
癌症
癌细胞
生物
生物信息学
病理
免疫学
内科学
细胞生物学
受体
作者
Albrecht Neeße,Christian Bauer,Daniel Öhlund,Matthias Lauth,Malte Buchholz,Patrick Michl,David A. Tuveson,Thomas M. Gress
出处
期刊:Gut
[BMJ]
日期:2018-09-03
卷期号:68 (1): 159-171
被引量:248
标识
DOI:10.1136/gutjnl-2018-316451
摘要
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance. Intensive research of recent years has revealed an incredible heterogeneity and complexity of the different components of the TME, including cancer-associated fibroblasts, immune cells, extracellular matrix components, tumour vessels and nerves. It has been hypothesised that paracrine interactions between neoplastic epithelial cells and TME compartments may result in either tumour-promoting or tumour-restraining consequences. A better preclinical understanding of such complex and dynamic network systems is required to develop more powerful treatment strategies for patients. Scientific activity and the number of compelling findings has virtually exploded during recent years. Here, we provide an update of the most recent findings in this area and discuss their translational and clinical implications for basic scientists and clinicians alike.
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