Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria

线粒体 细胞生物学 粒体自噬 线粒体分裂 自噬 氧化应激 程序性细胞死亡 褪黑素 生物 活性氧 线粒体凋亡诱导通道 细胞凋亡 DNM1L型 细胞色素c 生物化学 内分泌学
作者
Erica Cesarini,Liana Cerioni,Barbara Canonico,Gianna Di Sario,Andrea Guidarelli,Davide Lattanzi,David Savelli,Michele Guescini,Maria Gemma Nasoni,Noemi Bigini,Riccardo Cuppini,Vilberto Stocchi,Patrizia Ambrogini,Stefano Papa,Francesca Luchetti
出处
期刊:PLOS ONE [Public Library of Science]
卷期号:13 (8): e0203001-e0203001 被引量:13
标识
DOI:10.1371/journal.pone.0203001
摘要

Neurons contain a high number of mitochondria, these neuronal cells produce elevated levels of oxidative stress and live for a long time without proliferation; therefore, mitochondrial homeostasis is crucial to their health. Investigations have recently focused on mitochondrial dynamics revealing the ability of these organelles to change their distribution and morphology. It is known that mitochondrial fission is necessary for the transmission of mitochondria to daughter cells during mitosis and mitochondrial fragmentation has been used as an indicator of cell death and mitochondrial dysfunction. Oxidative stress is a trigger able to induce changes in the mitochondrial network. The aim of the present study was to determine the effects of melatonin on the mitochondrial network in HT22 serum-deprived cells. Our results showed that serum deprivation increased reactive oxygen species (ROS) content, promoted the activation of plasma membrane voltage-dependent anion channels (VDACs) and affected the expression of pDRP1 and DRP1 fission proteins. Moreover, parallel increases in apoptotic and autophagic features were found. Damaged and dysfunctional mitochondria are deleterious to the cell; hence, the degradation of such mitochondria through mitophagy is crucial to cell survival. Our results suggest that melatonin supplementation reduces cell death and restores mitochondrial function through the regulation of autophagy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
丁丁完成签到 ,获得积分10
2秒前
超帅沂完成签到,获得积分10
3秒前
4秒前
妙aaa完成签到,获得积分10
5秒前
5秒前
7秒前
koi发布了新的文献求助10
8秒前
坚定初柳完成签到 ,获得积分10
8秒前
xiaozou55完成签到 ,获得积分10
8秒前
9秒前
FashionBoy应助小猫宝采纳,获得10
10秒前
李鱼丸完成签到,获得积分10
10秒前
不执笔13发布了新的文献求助10
10秒前
cq完成签到,获得积分10
10秒前
yuminger发布了新的文献求助10
10秒前
11秒前
小马甲应助大小宇采纳,获得10
11秒前
祯果粒发布了新的文献求助10
14秒前
及桉应助小橙采纳,获得10
15秒前
谈笑间应助涵泽采纳,获得10
16秒前
16秒前
旺仔大馒头完成签到,获得积分10
17秒前
完美世界应助lmy采纳,获得10
19秒前
科研通AI5应助白河采纳,获得30
19秒前
21秒前
科研通AI2S应助楚辞采纳,获得10
21秒前
Orange应助小黄采纳,获得10
22秒前
情怀应助标致诗蕾采纳,获得10
22秒前
22秒前
科研通AI5应助liumuyi采纳,获得10
22秒前
23秒前
崔先生发布了新的文献求助10
23秒前
Orange应助文学痞采纳,获得10
24秒前
科研通AI2S应助Vicki采纳,获得10
24秒前
JIANG完成签到,获得积分10
25秒前
九九发布了新的文献求助10
25秒前
SciGPT应助老刘Diamond采纳,获得10
25秒前
莱贝特发布了新的文献求助10
26秒前
彭哒哒完成签到,获得积分10
26秒前
高分求助中
Basic Discrete Mathematics 1000
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3799882
求助须知:如何正确求助?哪些是违规求助? 3345154
关于积分的说明 10324069
捐赠科研通 3061756
什么是DOI,文献DOI怎么找? 1680519
邀请新用户注册赠送积分活动 807129
科研通“疑难数据库(出版商)”最低求助积分说明 763462