纤毛病
纤毛
生物
细胞生物学
细胞器
睫状体病
神经科学
遗传学
基因
表型
作者
Lei Wang,Brian David Dynlacht
出处
期刊:Development
[The Company of Biologists]
日期:2018-09-15
卷期号:145 (18)
被引量:146
摘要
The primary cilium is an antenna-like organelle assembled on most types of quiescent and differentiated mammalian cells. This immotile structure is essential for interpreting extracellular signals that regulate growth, development and homeostasis. As such, ciliary defects produce a spectrum of human diseases, termed ciliopathies, and deregulation of this important organelle also plays key roles during tumor formation and progression. Recent studies have begun to clarify the key mechanisms that regulate ciliary assembly and disassembly in both normal and tumor cells, highlighting new possibilities for therapeutic intervention. Here, we review these exciting new findings, discussing the molecular factors involved in cilium formation and removal, the intrinsic and extrinsic control of cilium assembly and disassembly, and the relevance of these processes to mammalian cell growth and disease.
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