Visible‐Light Photoredox Catalyzed Decarboxylative Alkylation of Vinylcyclopropanes

Abstract Herein, we report a visible‐light mediated photoredox catalyzed decarboxylative alkylation of vinylcyclopropanes. The reaction was carried out with an Ir‐based photocatalyst and Cs 2 CO 3 as a base. The desired functionalized long‐chained alkylated derivatives were obtained in 48–93% yields under mild reaction conditions without any external metal co‐catalysts, oxidants, or additives. Various alkyl carboxylic acids and amino acid derivatives are used as alkylating reagents to synthesize the γ,δ‐unsaturated diesters, and unnatural homo‐allylic amino acid derivatives with excellent functional groups tolerance. The utility of this method was showcased by performing a gram‐scale synthesis. A mechanism is proposed based on control experiments and quenching studies. magnified image