光热治疗
醛
光动力疗法
光敏剂
体内
自愈水凝胶
材料科学
纳米技术
化学
有机化学
催化作用
高分子化学
生物技术
生物
作者
Tianxing Chen,Teng-Teng Yao,Hui Pan,Hui Peng,Andrew K. Whittaker,Yao Li,Shenmin Zhu,Zhao-Yang Wang
出处
期刊:Nano Research
[Springer Nature]
日期:2022-06-14
卷期号:15 (9): 8636-8647
被引量:6
标识
DOI:10.1007/s12274-022-4455-7
摘要
Hypoxia is a huge barrier for the development of photodynamic therapy (PDT). Chemodynamic therapy (CDT) could provide a possible solution to this dilemma. In this work, a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots (CDs) and aldehyde groups on aldehyde-modified cellulose nanocrystals (mCNCs) as well as aldehyde-mCNCs decorated with Fe3O4 nanoparticles. In this process, the mCNCs not only prevent the agglomeration of Fe3O4 but also form hydrogels with CDs. The CDs act as both photothermal agent and photosensitizer. The hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe3O4, and the ·OH produced in the reaction further induces CDT and enhances tumor therapy efficiency. The therapy performance was further verified through in vitro cell experiments and in vivo animal experiments. This convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy.
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