生物能学
细胞生物学
串扰
骨重建
氧化磷酸化
细胞代谢
能量代谢
新陈代谢
糖酵解
线粒体
细胞
生物
化学
生物化学
内分泌学
物理
光学
作者
Rubens Sautchuk,Roman A. Eliseev
出处
期刊:Bone reports
[Elsevier]
日期:2022-06-01
卷期号:16: 101594-101594
被引量:17
标识
DOI:10.1016/j.bonr.2022.101594
摘要
Energy metabolism plays an important role in cell and tissue ability to effectively function, maintain homeostasis, and perform repair. Yet, the role of energy metabolism in skeletal tissues in general and in bone, in particular, remains understudied. We, here, review the aspects of cell energy metabolism relevant to bone tissue, such as: i) availability of substrates and oxygen; ii) metabolism regulatory mechanisms most active in bone tissue, e.g. HIF and BMP; iii) crosstalk of cell bioenergetics with other cell functions, e.g. proliferation and differentiation; iv) role of glycolysis and mitochondrial oxidative phosphorylation in osteogenic lineage; and v) most significant changes in bone energy metabolism observed in aging and other pathologies. In addition, we review available methods to study energy metabolism on a subcellular, cellular, tissue, and live animal levels.
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