Synthesis and characterization of nano CuO/ZnO/Al2O3 catalyst via Laser ablation route for the preparation of some cyanoacetanilide derivatives

The laser ablation technique can be considered as a promising and effective physical alternative route that may be used for the creation of nanoparticles.The main goal of this study is to synthesizeCuO/ZnO/Al2O3glass-ceramic nanoparticles in aqueous media using the laser ablation route in deionized water (DIW).Synthesized nanoparticles were employed for the synthesis of 2-cyano-2-( p -nitrobenzylidene)-p -methoxyacetanilide via Knoevenagel condensation reaction between pnitrobenzaldehyde and 2-cyano-N-(4methoxyphenyl) acetamide compounds.This protocol was used to obtain a high yield of the final product.The method is considered solvent-free, eco-friendly, short-time reaction, and excellent yield in comparison with that using the catalyst in its bulk form.The antibacterial properties of the synthesized products were evaluated against Gram-positive (Streptococcus bacteria) and Gram-negative bacteria (Enterococcus bacteria).