化学
亲核细胞
催化作用
选择性
氯丙烯
氯化物
药物化学
恶唑啉
联轴节(管道)
组合化学
亲核取代
烷基
有机化学
机械工程
工程类
作者
Marco A. Lopez,Joshua A. Buss,Shannon S. Stahl
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-12-29
卷期号:24 (2): 597-601
被引量:17
标识
DOI:10.1021/acs.orglett.1c04038
摘要
Site-selective chlorination of benzylic C-H bonds is achieved using a CuICl/bis(oxazoline) catalyst with N-fluorobenzenesulfonimide as the oxidant and KCl as a chloride source. This method exhibits higher benzylic selectivity, relative to established chlorination protocols, and is compatible with diverse alkyl arenes. Sequential benzylic C-H chlorination/nucleophilic substitution affords C-O, C-S, and C-N coupling products with oxidatively sensitive coupling partners.
科研通智能强力驱动
Strongly Powered by AbleSci AI