姜黄素
体外
化学
多糖
纳米颗粒
抗氧化剂
细胞凋亡
生物化学
生物物理学
纳米技术
材料科学
生物
作者
Jin Yang,Jieqiong Lin,Xianxiang Chen,Liyuan Rong,Mingyue Shen,Yuanxing Wang,Jianhua Xie
标识
DOI:10.1016/j.carbpol.2022.119875
摘要
The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP). Curcumin-loaded nanoparticles (ZMC NPs) were prepared. ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charge (-34.53 mV). Compared with free curcumin, encapsulated curcumin has been shown to have better environmental stability, higher antioxidant activity and bioaccesibility. The surface coating of zein NPs with MCP makes them more amenable to uptake by intestinal epithelial cells. Studies on in vitro antitumor activity of ZMC NPs showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ROS production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin. These results may contribute to the development of novel curcumin oral delivery systems.
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