免疫系统
肝细胞癌
抗原
癌症研究
粘蛋白
免疫疗法
转移
生物
免疫学
肿瘤抗原
医学
癌症
病理
遗传学
作者
Ayana R Kumar,Aswathy R Devan,Bhagyalakshmi Nair,Reshma Ravindran Nair,Lekshmi R Nath
出处
期刊:Current Cancer Drug Targets
[Bentham Science]
日期:2022-08-26
卷期号:22 (9): 725-740
被引量:4
标识
DOI:10.2174/1568009622666220317090552
摘要
Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC. HCC cells maintain an immune-suppressive environment with the help of immunesuppressive tumor-associated antigens, resulting in a metastatic spread of the disease. The development of intense immunotherapeutic strategies to target tumor-associated antigen is critical to overcoming the progression of HCC. MUC 1 remains the most recognized tumor-associated antigen since its discovery over 30 years ago. A few promising immunotherapies targeting MUC 1 are currently under clinical trials, including CAR-T and CAR-pNK-mediated therapies. This review highlights the biosynthesis, significance, and clinical implication of MUC 1 as an immune target in HCC.
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