区域选择性
磷酸
催化作用
化学
吲哚试验
醌
组合化学
反应条件
有机化学
作者
Biquan Xiong,Lulu Si,Yu Liu,Weifeng Xu,Tao Jiang,Fan Cao,Kewen Tang,Wai‐Yeung Wong
标识
DOI:10.1002/asia.202200042
摘要
An efficient, cheap and green protocol for the highly regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with indoles at the C-3 position has been established by phosphoric acid catalysis in water under transition-metal-free reaction conditions. A wide range of indole derivatives and para-quinone methides (p-QMs) are compatible for the reaction, affording the corresponding 1,6-hydroarylation products with good to excellent yields. The possible mechanism of the reaction has been explored through step-by-step control experiments. The protocol is convenient for practical applications, leading to a safe, green and feasible way for the formation of C-3 diarylmethyl functionalized indole derivatives.
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