卤素
卤化
离子键合
化学
反应性(心理学)
组合化学
戒指(化学)
药物化学
级联
碘
卤化物
原子经济
级联反应
有机化学
离子
催化作用
医学
病理
替代医学
色谱法
烷基
作者
Jinhuan Dong,Junlin Hu,Xiaoli Liu,Shaoguang Sun,Lan Bao,Mengying Jia,Xianxiu Xu
标识
DOI:10.1021/acs.joc.1c02747
摘要
An ionic cascade insertion/cyclization reaction of thia-/selena-functionalized arylisocyanides has been successfully developed for the efficient and practical synthesis of 2-halobenzothiazole/benzoselenazole derivatives. This synthetic protocol, incorporating a halogen atom when forming the five-membered ring of benzothia/selenazoles, is different from the existing ones, where halogenation of the preformed benzothia/selenazole precursors happens. Additionally, a facile access to 2-aminobenzothiazoles is also achieved by the one-pot cascade reaction of 2-isocyanoaryl thioethers, iodine, and amines.
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