The Nuclear Overhauser Effect in Structural and Conformational Analysis

This book is a comprehensive treatment of the nuclear Overhauser effect (NOE), an important branch of NMR spectroscopy concerned with structural and conformational problems. It is the only text in this area since 1971. Since that time there have been tremendous changes in the area, particularly with the growth of experiments such as NOE difference spectroscopy, NOESY, the heteronuclear NOE, with applications to an ever-increasing variety of structural and conformational problems in chemistry and biochemistry. The book gives a very clear and integrated account of all these developments. It covers theory, experimental practice, and applications in a unified manner including the influence of exchange and spin-spin-coupling as part of its underlying concepts, and applications to molecules as diverse as cyclobutanes and proteins. The book is of interest primarily to postgraduate organic and inorganic chemists and biochemists who use the NOE in their research, but it is also useful to those who wish to learn the background to the technique, for instance computational chemists , biophysicists, and physical chemists. Although it describes and explains the latest developments, the treatment is suitable for those with only a graduate-level background in chemistry and spectroscopy.