PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: REPORT OF FOUR CASES, WITH OBSERVATIONS ON TREATMENT WITH 3,3′-METHYLENEBIS (4-HYDROXYCOUMARIN) (DICUMAROL)

Article1 December 1955PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: REPORT OF FOUR CASES, WITH OBSERVATIONS ON TREATMENT WITH 3,3′-METHYLENEBIS (4-HYDROXYCOUMARIN) (DICUMAROL)HERBERT A. PERKINS, M.D., J. M. BOULWARE, M.D., T. V. FEICHTMEIR, M.D., WILLIAM W. THAYER, M.D., THEODORE H. SPAET, M.D.HERBERT A. PERKINS, M.D., J. M. BOULWARE, M.D., T. V. FEICHTMEIR, M.D., WILLIAM W. THAYER, M.D., THEODORE H. SPAET, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-6-1218 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParoxysmal nocturnal hemoglobinuria (PNH) is a chronic hemolytic anemia characterized clinically by hemoglobinuria, exacerbation of the hemolytic process during sleep, leukopenia, thrombocytopenia, and a marked tendency to spontaneous thrombosis. The hemolysis has been demonstrated to be due to an acquired defect of the red blood cells, the cause of this defect being completely unknown. These defective cells are abnormally susceptible to hemolysis in their own or homologous normal serum.Considerable work has been done in an effort to elucidate the mechanism of the hemolytic system. Ham and others, working in the late 1930's demonstrated that PNH red cells are readily...Bibliography1. Ham TH: Studies on destruction of red blood cells: chronic hemolytic anemia with paroxysmal nocturnal hemoglobinuria: investigation of mechanism of hemolysis, with observation on five cases, Arch. Int. Med. 64: 1271, 1939. CrossrefGoogle Scholar2. CrosbyDameshek WHW: Paroxysmal nocturnal hemoglobinuria. The mechanism of hemolysis and its relation to the coagulation mechanism, Blood 5: 822, 1950. CrossrefMedlineGoogle Scholar3. Crosby WH: Paroxysmal nocturnal hemoglobinuria. A specific test for the disease based on the ability of thrombin to activate the hemolytic factor, Blood 5: 843, 1950. CrossrefMedlineGoogle Scholar4. Crosby WH: Paroxysmal nocturnal hemoglobinuria. Plasma factors of the hemolytic system, Blood 8: 444, 1953. CrossrefMedlineGoogle Scholar5. Crosby WH: Paroxysmal nocturnal hemoglobinuria. Relation of the clinical manifestations to underlying pathogenic mechanisms, Blood 8: 769, 1953. CrossrefMedlineGoogle Scholar6. FeichtmeierBoulwareWillettPerkins TJFH: Paroxysmal nocturnal hemoglobinuria complicated by acquired hemolytic anemia treated with cortisone, J. Lab. and Clin. Med. 46: 443, 1955. MedlineGoogle Scholar7. SpaetRosenthalDameshek THMGW: Idiopathic myoglobinuria in man. Report of case, Blood 9: 881, 1954. CrossrefMedlineGoogle Scholar8. Dacie JV: The hemolytic anemias, congenital and acquired, 1954, Grune and Stratton, New York. Google Scholar9. Ham TH: A syllabus of laboratory examinations in clinical diagnosis, 1952, Harvard University Press, Cambridge. Google Scholar10. GouttasTsevrenisPoungourasFassas AHPP: Cas d'hémoglobinurie paroxystique type Marchiafava-Micheli avec test de Crosby positif, Sang 25: 851, 1954. MedlineGoogle Scholar11. Marks J: The Marchiafava-Micheli syndrome. Paroxysmal nocturnal hemoglobinuria, Quart. J. Med. 18: 105, 1949. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 11, 1955.From the Departments of Medicine of Stanford University School of Medicine, and the Fort Miley Veterans Administration Hospital, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCerebral Venous Thrombosis in Paroxysmal Nocturnal HemoglobinuriaCerebral Ischemic Infarction in Paroxysmal Nocturnal HemoglobinuriaParoxysmal Nocturnal Haemoglobinuria in Aplastic AnaemiaPlatelet hypersensitivity and intravascular coagulation in paroxysmal nocturnal hemoglobinuriaThe sickle cell paroxysmal nocturnal hemoglobinuria syndromeThromboplastic Activity of the Plasma in Paroxysmal Nocturnal HaemoglobinuriaProperdin und H�molyse 1 December 1955Volume 43, Issue 6Page: 1218-1229KeywordsAplastic anemiaAttentionBlood plasmaCellsHemoglobinHemolytic anemiaHospital medicineRed blood cellsSleepThrombosis Issue Published: 1 December 1955 PDF downloadLoading ...