多发性硬化
脱髓鞘病
视神经脊髓炎
发病机制
急性播散性脑脊髓炎
中枢神经系统
神经退行性变
病理
医学
病态的
神经科学
脑脊髓炎
炎症
免疫学
疾病
生物
作者
Bogdan F. Gh. Popescu,Claudia F. Lucchinetti
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2012-02-28
卷期号:7 (1): 185-217
被引量:305
标识
DOI:10.1146/annurev-pathol-011811-132443
摘要
There has been significant progress in our understanding of the pathology and pathogenesis of central nervous system inflammatory demyelinating diseases. Neuropathological studies have provided fundamental new insights into the pathogenesis of these disorders and have led to major advances in our understanding of multiple sclerosis (MS) heterogeneity, the substrate of irreversible progressive disability in MS, the relationship between inflammation and neurodegeneration in MS, the neuroimaging correlates of MS lesions, and the pathogenesis of other central nervous system inflammatory disorders, including neuromyelitis optica, acute disseminated encephalomyelitis, and Balo's concentric sclerosis. Herein, we review the pathological features of these central nervous system inflammatory demyelinating disorders and discuss neuropathological studies that have yielded novel insights into potential mechanisms involved in the formation of the demyelinated lesion.
科研通智能强力驱动
Strongly Powered by AbleSci AI