偶氮苯
自愈水凝胶
化学
透明质酸
机械生物学
微流变学
药物输送
超分子化学
环糊精
聚合物
纳米技术
生物物理学
分子
高分子化学
有机化学
粘弹性
材料科学
生物
复合材料
遗传学
作者
Adrianne M. Rosales,Christopher B. Rodell,Minna H. Chen,Matthew G. Morrow,Kristi S. Anseth,Jason A. Burdick
标识
DOI:10.1021/acs.bioconjchem.7b00802
摘要
Biomimetic hydrogels fabricated from biologically derived polymers, such as hyaluronic acid (HA), are useful for numerous biomedical applications. Due to the dynamic nature of biological processes, it is of great interest to synthesize hydrogels with dynamically tunable network properties where various functions (e.g., cargo delivery, mechanical signaling) can be changed over time. Among the various stimuli developed to control hydrogel properties, light stands out for its exquisite spatiotemporal control; however, most light-based chemistries are unidirectional in their ability to manipulate network changes. Here, we report a strategy to reversibly modulate HA hydrogel properties with light, using supramolecular cross-links formed via azobenzene bound to β-cyclodextrin. Upon isomerization with 365 nm or 400–500 nm light, the binding affinity between azobenzene and β-cyclodextrin changed and altered the network connectivity. The hydrogel mechanical properties depended on both the azobenzene modification and isomeric state (lower for cis state), with up to a 60% change in storage modulus with light exposure. Furthermore, the release of a fluorescently labeled protein was accelerated with light exposure under conditions that were cytocompatible to encapsulated cells. These results indicate that the developed hydrogels may be suitable for applications in which temporal regulation of material properties is important, such as drug delivery or mechanobiology studies.
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