期刊：Science [American Association for the Advancement of Science (AAAS)] 日期：2018-04-05卷期号：360 (6384): 44.18-46
标识
DOI：10.1126/science.360.6384.44-r
摘要
Neurodegeneration
The kinase LRRK2 is activated by mutation in a subset of patients with Parkinson's disease, making it a possible therapeutic target. In a Perspective, Alessi and Sammler discuss the possible mechanisms leading to Parkinson's disease in patients with LRRK2 activation. In particular
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