脂肪生成
白色脂肪组织
脂肪组织
脂质代谢
代谢物
柠檬酸循环
生物化学
内科学
内分泌学
内分泌系统
代谢途径
生物
新陈代谢
化学
激素
医学
作者
Jessica B. Felix,Aaron R. Cox,Sean M. Hartig
标识
DOI:10.1016/j.tem.2021.02.008
摘要
White adipose tissue (WAT) depends on coordinated regulation of transcriptional and metabolic pathways to respond to whole-body energy demands. We highlight metabolites that contribute to biosynthetic reactions for WAT expansion. Recent studies have precisely defined how byproducts of carbohydrate and lipid metabolism affect physiological and endocrine functions in adipocytes. We emphasize the critical emerging roles of short-chain fatty acids (SCFAs) and tricarboxylic acid (TCA) cycle metabolites that connect lipogenesis to WAT energy balance and endocrine functions. These insights address how adipocytes use small molecules generated from central carbon metabolism to measure responses to nutritional stress.
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