抗氧化剂
氧化应激
过氧化物酶
谷胱甘肽
谷胱甘肽过氧化物酶
酶
生物化学
生物
化学
作者
Mars G. Shaparov,Sergey V. Gudkov,В. З. Ланкин,В. И. Новоселов
出处
期刊:Biokhimiya
[Springer Nature]
日期:2021-11-01
卷期号:86 (11): 1418-1433
被引量:13
标识
DOI:10.1134/s0006297921110067
摘要
In this review, we discuss the pathogenesis of some socially significant diseases associated with the development of oxidative stress, such as atherosclerosis, diabetes, and radiation sickness, as well as the possibilities of the therapeutic application of low-molecular-weight natural and synthetic antioxidants for the correction of free radical-induced pathologies. The main focus of this review is the role of two phylogenetically close families of hydroperoxide-reducing antioxidant enzymes peroxiredoxins and glutathione peroxidases - in counteracting oxidative stress. We also present examples of the application of exogenous recombinant antioxidant enzymes as therapeutic agents in the treatment of pathologies associated with free-radical processes and discuss the prospects of the therapeutic use of exogenous antioxidant enzymes, as well as the ways to improve their therapeutic properties.
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