医学
陶氏病
表位
病态的
Tau病理学
单克隆抗体
疾病
阿尔茨海默病
τ蛋白
神经科学
生物信息学
心理学
生物
病理
免疫学
抗体
神经退行性变
作者
Bruno P. Imbimbo,Stefania Ippati,Mark Watling,Claudia Balducci
摘要
Primary tauopathies are neurological disorders in which tau protein deposition is the predominant pathological feature. Alzheimer's disease is a secondary tauopathy with tau forming hyperphosphorylated insoluble aggregates. Tau pathology can propagate from region to region in the brain, while alterations in tau processing may impair tau physiological functions.We reviewed literature on tau biology and anti-tau drugs using PubMed, meeting abstracts, and ClnicalTrials.gov.The past 15 years have seen >30 drugs interfering with tau aggregation, processing, and accumulation reaching the clinic. Initial results with tau aggregation inhibitors and anti-tau monoclonal antibodies have not shown clinical efficacy.The reasons for these clinical failures are unclear but could be linked to the clearing of physiological forms of tau by non-specific drugs. Research is now concentrating efforts on developing reliable translational animal models and selective compounds targeting specific tau epitopes, neurotoxic tau aggregates, and post-translational tau modifications.
科研通智能强力驱动
Strongly Powered by AbleSci AI