慢性疼痛
认知
神经反射
神经科学
心理学
感觉系统
感知
生物神经网络
痛觉
医学
物理医学与康复
脑电图
物理疗法
作者
Nicole Mercer Lindsay,Chong Chen,Gadi Gilam,Sean Mackey,Grégory Scherrer
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2021-11-10
卷期号:13 (619)
被引量:70
标识
DOI:10.1126/scitranslmed.abj7360
摘要
Pain is a multidimensional experience with sensory-discriminative, affective-motivational, and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering for patients with chronic pain, motivating research and drug development efforts to investigate and modulate neural activity in the brain’s circuits encoding pain unpleasantness. Here, we review progress in understanding the organization of emotion, motivation, cognition, and descending modulation circuits for pain perception. We describe the molecularly defined neuron types that collectively shape pain multidimensionality and its aversive quality. We also review how pharmacological, stimulation, neurofeedback, surgical, and cognitive-behavioral interventions alter activity in these circuits to relieve chronic pain.
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