Aptamer based switches: A futuristic approach for Helicobacter pylori detection

Helicobacter pylori (H. pylori) is a bacterium that belongs to the gram-negative group inhabits the mucosa of human stomach diseases and has been implicated in causing gastric cancer and other gastric diseases. The limitation of conventional techniques has encouraged the progress of other innovative methods due to their cost-effective, reliable, and rapid H. pylori detection. Aptamers are RNA/DNA single-stranded oligonucleotides that can be specifically recognized and attached to their target molecules and their use in diagnostic applications. Currently, aptamer-based sensing platforms have shown to be promising for applications like detecting many viral and bacterial pathogens from food and clinical specimens. This review offers an outline of the aptamer-based system as a futuristic and novel method for H. pylori detection.