类鼻疽伯克霍尔德菌
内化
佐剂
类鼻疽
肿瘤微环境
抗原
CpG寡核苷酸
材料科学
微生物学
癌症研究
免疫系统
生物
免疫学
细菌
细胞
生物化学
基因
基因表达
DNA甲基化
遗传学
作者
Feng-Ying Huang,Shuzhen Dai,Jinyan Wang,Yingying Lin,Cai-chun Wang,Wuping Zheng,Guang-Hong Tan
出处
期刊:Biomaterials
[Elsevier]
日期:2021-06-10
卷期号:278: 121141-121141
被引量:3
标识
DOI:10.1016/j.biomaterials.2021.121141
摘要
Due to its size, shape, and inherent expression of pathogen-associated molecular patterns and invasion-assistant adhesion proteins , Burkholderia pseudomallei can easily attach to, and then be internalized by, dendritic cells (DCs), leading to more efficient antigen cross-presentation if modified as carrier. Herein, we engineered Burkholderia pseudomallei as a porous/hollow carrier (SB) for loading tumor lysates (L) and adjuvant CpG (C) to be used as a tumor vaccine (SB-LC). We found that the adhesion proteins of Burkholderia pseudomallei promote internalization of the SB-LC vaccine by DCs, and result in enhanced DC maturation and antigen cross-presentation. SB-LC induces robust cellular and humoral antitumor responses that synergistically inhibit tumor growth with minimal adverse side effects in several tumor models. Moreover, SB-LC vaccination reverses the immunosuppressive tumor microenvironment , apparently as a result of CD8 + -induced tumor ferroptosis . Thus, SB-LC is a potential model tumor vaccine for translating into a clinically viable treatment option.
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